Back from tea, with Cheteshwar Pujara and Rohit Sharma are in the middle and Vernon Philander bowling, India is at 202/2.
South Africa was bowled out for 431 in 131.2 overs in their first innings reply to India's 502 for 7 declared on the fourth day morning of the opening Test at Vishakapatnam on Saturday.
Off-spinner Ravichandran Ashwin took seven wickets and South Africa was trailing by 171 runs.
Pujara brought up a 50 in style only to get out soon after, bringing Ravinder Jadeja to the crease.
Jadeja hit a six after responding to a call to a single by Sharma.
The first hour of play has kept the run rate accelerated for India.