Though Uruguay's Giorgian de Arrascaeta scored twice against Ghana, both teams got eliminated from the World Cup on Friday.
Uruguay beat Ghana 2-0 but it was not enough to keep them in the World Cup after South Korea pipped them to the Group H runners-up spot with a victory over Portugal.
Ghana, who famously missed an extra-time spot-kick in a quarter-final against Uruguay in South Africa 12 years ago, spurned the chance to take the lead in the 21st minute when Andre Ayew's tame penalty was easily saved by Sergio Rochet.
Uruguay made them pay with their first goals of the tournament as De Arrascaeta headed the ball over the line from close-range after a shot from Luis Suarez in the 26th minute and doubled their lead with a superb volley after Suarez was again involved in the buildup six minutes later.
The win lifted Uruguay to the third place in Group H but South Korea managed to qualify for knockout winning against Portugal. Ghana, with three points, finished bottom of the group.