The engine and five coaches of the Nagpur-Mumbai Duronto Express derailed on early Tuesday morning near the Titwala station, a small town in Maharashtra's Kalyan.
A rescue team has been dispatched from Kalyan to the accident site. As per preliminary information, more than 20 passengers have been injured in the incident, which occurred at around 6.30am.
As a result of the derailment, the suburban local train services of the Central Railway in Mumbai and Thane were affected hitting morning peak hours and commuter traffic.
On August 25, a local train running on Mumbai's Harbour line derailed, while it was returning to the Mahim platform.
Saving the first four coaches, a technical fault caused the derailment of coaches six, seven, eight, and nine. Around six persons sustained minor injuries, but no case of casualties or major injuries were recorded.
The derailment has taken place just few days after the Delhi-bound Kaifiyat Express derailed in Uttar Pradesh's Auraiya district on August 23. As many as 81 people were injured.
On August 19, the Kalinga-Utkal Express had also derailed in Uttar Pradesh's Muzaffarnagar killing 22 people and injuring over 200.
In the aftermath, Railway Minister Suresh Prabhu had offered to resign, taking moral responsibility for the accidents under his watch, but was asked by Prime Minister Narendra Modi to "wait".
